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The ''glnA'' RNA motif is a conserved RNA structure that was predicted by bioinformatics. It is present in a variety of lineages of cyanobacteria, as well as some phages that infect cyanobacteria. It is also found in DNA extracted from uncultivated bacteria living in the ocean that are presumably species of cyanobacteria. ''glnA'' RNAs are found in the presumed 5' untranslated regions of genes encoding multiple classes of protein that are involved in nitrogen metabolism. The most prominent of these protein classes are ammonium transporters, the enzymes glutamine synthetase and glutamate synthase and PII protein, which itself regulates nitrogen metabolism. Further supporting a possible role as a cis-regulatory element in control of nitrogen metabolism, the ''Prochlorococcus marinus'' gene designed as PMT1479 was more repressed than another other gene in this organism when it was growth without a sufficient supply of nitrogen.〔 It was demonstrated that ''glnA'' RNAs correspond to glutamine-binding riboswitches, i.e., they sense glutamine concentrations in order to measure overall nitrogen availability, and regulate the downstream genes appropriately. The original proposal of a riboswitch function was based on the above evidence that ''glnA'' RNAs are ''cis''-regulatory, as well as the moderate structural complexity in the three-stem junction of the ''glnA'' RNA motif that is comparable to the structures of other known riboswitches. Some ''glnA'' RNAs are located adjacent to other ''glnA'' RNAs. These "tandem arrangements" are also exhibited by glycine riboswitches and TPP riboswitches where they allow the cell to turn genes off or on within a smaller change of concentration of the riboswitch ligand. In other words, the response curve of the riboswitch better resembles a digital function. However, such cooperative binding was not observed.〔 A possible structural resemblance was observed between the ''glnA'' RNA motif and the Downstream-peptide motif.〔 The most apparent similarity is between the stems labeled "P1" in each motif, but other similarities were observed.〔 It was proposed that both motifs represent riboswitches involved in nitrogen metabolism. The fact that RNAs from both motifs selectively bind glutamine supports this hypothesis, but detailed structural data is not yet available. The ''glnA'' motif has an E-loop structure (also called a bulged-G module) within it. ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「GlnA RNA motif」の詳細全文を読む スポンサード リンク
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